![]() ![]() The study should not be susceptible to bias as there is no perceived association between those participants who either wish to take part in the study or subsequently choose to collect and return the specimen, and their baby's urinary sodium level. All confounding factors will be measured on a data-sheet accompanying the specimen (sex, weight, method of feeding and medications). This design has been chosen to obtain an unbiased sample group, with minimal inconvenience or risk to participants. Participants will be required to collect a sample of urine at 6 weeks post-natal age (they will be provided with a standardized means to collect the specimen) and return it to the investigators in a pre-paid, pre-addressed envelope (UN602 compliant packaging). The population being studied is healthy term (37-41 week gestation) babies with no significant ante- or post-natal history born within the study period in a single maternity unit. The study has been designed as a cross sectional study where participants details are recorded at birth, followed by a second time point at 6 weeks of age when a corresponding sample of urine will be obtained. Condition or diseaseĮlectrolyte Depletion Stoma Ileostomy Stoma Colostomy Growth Failure There are no documented ranges for the levels of urinary sodium in healthy, newborn babies.īy determining the reference range of urinary sodium levels in healthy, term babies who are gaining weight appropriately, the investigators hope to be able to have a better understanding about both the level below which supplementation should be considered and the target range that should be aimed for. ![]() In Glasgow, babies with poor weight gain are given sodium supplementation if urinary sodium levels are below 40 mmol/L. Some centres advise below 20 mmol/L (Birmingham Children's Hospital and Nottingham Children's Hospital guidelines), others below 10 mmol/L (University Children's Hospital, Zurich). Low levels of urinary sodium are considered to represent a state of low body sodium levels, as the kidneys attempt to reabsorb most of the sodium in the urine before it is excreted.Ĭurrent practice varies widely as to the level below which treatment should be instigated. those with a stoma) are currently administered oral sodium supplementation if they are failing to gain weight and have an associated 'low' urinary sodium level. Babies with conditions where they are at risk of salt depletion (i.e. It is believed that by increasing the level of salt in the intestine, glucose can be more easily be absorbed and therefore weight gain improved. This study aims to ascertain the normal range of sodium in urine specimens collected from healthy newborn babies. The decision to start oral supplementation is based on urinary sodium levels although the level at which to start treatment is variable as the range in normal, healthy infants is unknown. Oral sodium supplementation is currently administered in cases of poor weight gain in infants particularly in patients who have undergone gastrointestinal surgical procedures. ![]() Why Should I Register and Submit Results?. ![]()
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